Aggrecan Antikörper

Produktnummer ABIN1450192

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Aggrecan in WB, IP, IHC (p), IHC (fro) und EIA. Er zeigt eine Reaktivität gegenüber Human und Rind (Kuh) und wurde in 1 Publikation erwähnt.

Kurzübersicht für Aggrecan Antikörper (ABIN1450192)

Target: Aggrecan (ACAN)

Reaktivität: Human, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Aggrecan Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: HAG7D4 (7D4)

Produktdetails anti-Aggrecan Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Human and Bovine.

Aufreinigung: Prepared by Affinity Chromatography on Protein G from Tissue Culture Supernatant

Immunogen: Purified Human articular cartilage Aggrecan. Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the lyophilized product at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.

Referenzen für anti-Aggrecan Antikörper (ABIN1450192)

Anders, Mollenhauer, Beberhold, Kinne, Venbrocks: "Gelatin-based haemostyptic Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix?: an experimental study with bovine chondrocytes." in: The Journal of bone and joint surgery. British volume, Vol. 91, Issue 3, pp. 409-16, (2009) (PubMed).

Details zu Aggrecan

Target: Aggrecan (ACAN)

Andere Bezeichnung: Aggrecan

Hintergrund: Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.Synonyms: ACAN, AGC1, CSPG1, Cartilage-specific proteoglycan core protein, Chondroitin sulfate proteoglycan core protein 1, MSK16

Gen-ID: 176, 9606

UniProt: P16112

Pathways: Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport