SIGLEC15 Antikörper (N-Term)

Produktnummer ABIN1450134

Dieses Anti-SIGLEC15-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIGLEC15 in WB und IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für SIGLEC15 Antikörper (N-Term) (ABIN1450134)

Target: SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIGLEC15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SIGLEC15 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität (Details): Species reactivity (expected):Human, Mouse, Rat.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid synthetic peptide near the amino terminus of Human SIGLEC15

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1 - 2 ug/mL, IHC: 2.5 ug/mL
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SIGLEC15

Target: SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))

Andere Bezeichnung: SIGLEC15 / CD33L3

Hintergrund: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.Synonyms: CD33 antigen-like 3, SIGLEC-15, Sialic acid-binding Ig-like lectin 15

Gen-ID: 284266

NCBI Accession: NP_998767