RGS22 Antikörper (N-Term)

Produktnummer ABIN1449995

Der Kaninchen Polyklonal anti-RGS22 Antikörper wird verwendet zum Nachweis von RGS22 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IF und EIA.

Kurzübersicht für RGS22 Antikörper (N-Term) (ABIN1449995)

Target: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGS22 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-RGS22 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: A 19 amino acid synthetic peptide near the amino terminus of Human RGS22

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu RGS22

Target: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Andere Bezeichnung: RGS22

Hintergrund: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit (1,2). RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.Synonyms: Regulator of G-protein signaling 22

Molekulargewicht: 139 kDa

Gen-ID: 26166

NCBI Accession: NP_056483

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling