CARD14 Antikörper (C-Term)

Produktnummer ABIN1449966

Dieses Anti-CARD14-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CARD14 in IHC (p) und EIA. Geeignet für Human.

Kurzübersicht für CARD14 Antikörper (C-Term) (ABIN1449966)

Target: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD14 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-CARD14 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Affinity Chromatography purified via peptide column

Immunogen: 14 amino acid synthetic peptide near the carboxy terminus of Human CARMA2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CARD14

Target: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Andere Bezeichnung: CARD14 / CARMA2

Hintergrund: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein activated NF-kB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-kB activation and endoplasmic reticulum stress-induced cell death.Synonyms: CARD-containing MAGUK protein 2, Caspase recruitment domain-containing protein 14

Gen-ID: 79092

NCBI Accession: NP_077015