TTBK2 Antikörper (C-Term)

Produktnummer ABIN1449960

Der Kaninchen Polyklonal anti-TTBK2 Antikörper (ABIN1449960) detektiert spezifisch TTBK2 in IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TTBK2 Antikörper (C-Term) (ABIN1449960)

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TTBK2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-TTBK2 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid synthetic peptide near the carboxy terminus of Human TTBK2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu TTBK2

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Andere Bezeichnung: TTBK2

Hintergrund: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.Synonyms: KIAA0847, Tau-tubulin kinase 2

Gen-ID: 146057