DELE1/KIAA0141 Antikörper (N-Term)

Produktnummer ABIN1449949

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DELE1/KIAA0141 in WB, IF und EIA. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für DELE1/KIAA0141 Antikörper (N-Term) (ABIN1449949)

Target: DELE1/KIAA0141 (DELE1) (DAP3 Binding Cell Death Enhancer 1 (DELE1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DELE1/KIAA0141 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-DELE1/KIAA0141 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid synthetic peptide near the amino terminus of Human DELE

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu DELE1/KIAA0141

Target: DELE1/KIAA0141 (DELE1) (DAP3 Binding Cell Death Enhancer 1 (DELE1))

Andere Bezeichnung: KIAA0141

Hintergrund: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

Gen-ID: 9812

NCBI Accession: NP_055588