AKTIP Antikörper (Middle Region)
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- Target Alle AKTIP Antikörper anzeigen
- AKTIP (AKT Interacting Protein (AKTIP))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Huhn, Xenopus laevis
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser AKTIP Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA
- Kreuzreaktivität (Details)
- Species reactivity (expected):Mouse, Rat, Chicken, Dog, African clawed frog, ZebrafishSpecies reactivity (tested):Human
- Aufreinigung
- Purified using peptide immunoaffinity column
- Immunogen
- Synthetic peptide directed towards the middle region of human AKTIP
- Top Product
- Discover our top product AKTIP Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Rekonstitution
- Add 50 μL of distilled water to a final concentration of 1 mg/mL.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
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- Target
- AKTIP (AKT Interacting Protein (AKTIP))
- Andere Bezeichnung
- AKTIP / FTS (AKTIP Produkte)
- Synonyme
- FT1 antikoerper, FTS antikoerper, cb798 antikoerper, fts antikoerper, zgc:77699 antikoerper, fts-A antikoerper, aktip antikoerper, fts-B antikoerper, MGC133931 antikoerper, AL023020 antikoerper, Fif antikoerper, Ft antikoerper, Ft1 antikoerper, Fts antikoerper, AKT interacting protein antikoerper, akt interacting protein antikoerper, AKT interacting protein L homeolog antikoerper, AKT interacting protein S homeolog antikoerper, thymoma viral proto-oncogene 1 interacting protein antikoerper, AKTIP antikoerper, aktip antikoerper, aktip.L antikoerper, aktip.S antikoerper, Aktip antikoerper
- Hintergrund
- AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.Synonyms: AKT-interacting protein, FT1, Fused toes protein homolog
- Gen-ID
- 64400
- NCBI Accession
- NP_001012398
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