AKTIP Antikörper (Middle Region)

Produktnummer ABIN1449900

Dieses Anti-AKTIP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von AKTIP in WB. Geeignet für Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Huhn und Xenopus laevis.

Kurzübersicht für AKTIP Antikörper (Middle Region) (ABIN1449900)

Target: AKTIP (AKT Interacting Protein (AKTIP))

Reaktivität: Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Huhn, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKTIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-AKTIP Antikörper

Bindungsspezifität: Middle Region

Sequenz: NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Chicken, Dog, African clawed frog, ZebrafishSpecies reactivity (tested):Human

Aufreinigung: Purified using peptide immunoaffinity column

Immunogen: Synthetic peptide directed towards the middle region of human AKTIP

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu AKTIP

Target: AKTIP (AKT Interacting Protein (AKTIP))

Andere Bezeichnung: AKTIP / FTS

Hintergrund: AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.Synonyms: AKT-interacting protein, FT1, Fused toes protein homolog

Gen-ID: 64400

NCBI Accession: NP_001012398