ARNTL2 Antikörper (N-Term)

Produktnummer ABIN1449870

Der Kaninchen Polyklonal anti-ARNTL2 Antikörper (ABIN1449870) detektiert spezifisch ARNTL2 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Huhn.

Kurzübersicht für ARNTL2 Antikörper (N-Term) (ABIN1449870)

Target: ARNTL2 (Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2 (ARNTL2))

Reaktivität: Human, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARNTL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ARNTL2 Antikörper

Bindungsspezifität: N-Term

Sequenz: PTAMGSFSSH MTEFPRKRKG SDSDPSQSGI MTEKVVEKLS QNPLTYLLST

Kreuzreaktivität (Details): Species reactivity (expected):ChickenSpecies reactivity (tested):Human.

Aufreinigung: Purified using peptide immunoaffinity column

Immunogen: Synthetic peptide directed towards the N terminal of human ARNTL2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C for one month or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Details zu ARNTL2

Target: ARNTL2 (Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2 (ARNTL2))

Andere Bezeichnung: ARNTL2 / BMAL2

Hintergrund: ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, ARNTL2 activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. It is xxpressed in fetal brain and highly expressed in brain and placenta. Lower levels are found in heart, liver, thymus, kidney and lung. It is located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN) and also detected in endothelial cells of the heart, lung and kidney. In the brain, it is specifically expressed in the thalamus, hippocampus and amygdala.Synonyms: Aryl hydrocarbon receptor nuclear translocator-like protein 2, BHLHE6, Basic-helix-loop-helix-PAS protein MOP9, Brain and muscle ARNT-like 2, CLIF, CYCLE-like factor, Class E basic helix-loop-helix protein 6, MOP9, Member of PAS protein 9, PAS domain-containing protein 9, PASD9, bHLHe6

Gen-ID: 56938

NCBI Accession: NP_064568

Pathways: Photoperiodism