Integrin beta 3 Antikörper
Kurzübersicht für Integrin beta 3 Antikörper (ABIN1449278)
Target
Alle Integrin beta 3 (ITGB3) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Kreuzreaktivität (Details)
- Species reactivity (tested):Mouse. Not Human (PBCM cells on Flow cytometry).
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Aufreinigung
- Protein G agarose
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Immunogen
- Mouse platelet
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Isotyp
- IgG2a
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1.0 mg/mL
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Buffer
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
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Konservierungsmittel
- Without preservative
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Handhabung
- Avoid repeated freezing and thawing.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Upon receipt, store (in aliqouts) at -20 °C.
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- Integrin beta 3 (ITGB3)
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Andere Bezeichnung
- CD61 / ITGB3
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Hintergrund
- Platelet activation results in a conformational change of the membrane spanning platelet integrin GPIIb/IIIa (aIIbß3, CD41/CD61) enabling the binding of the plasma protein fibrinogen. This binding is primarily reversible, but it enhances platelet activation by outside-in signal causing receptor clustering, platelet secretion, and finally irreversible fibrinogen binding and platelet aggregation.Synonyms: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
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Gen-ID
- 10090
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UniProt
- O54890
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Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
Target
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