FOXP3 Antikörper (FITC)

Produktnummer ABIN1449249

Dieses Anti-FOXP3-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von FOXP3 in FACS. Geeignet für Maus.

Kurzübersicht für FOXP3 Antikörper (FITC) (ABIN1449249)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser FOXP3 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Klon: MF-14

Produktdetails anti-FOXP3 Antikörper (FITC)

Spezifität: This antibody reacts with mouse Foxp3.

Aufreinigung: Protein G agarose

Immunogen: Recombinant full-length mouse Foxp3

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 50 tests in 1 mLvolume of PBS containing 1 % BSA and 0.09 % NaN3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8 °C.

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: FOXP3

Hintergrund: Forkhead-winged helix P3 (Foxp3), also known as Scurfin or JM2, is a 50-55 kDa transcription factor, originally identified as the gene defective in Scurfy mice. Scurfy mice and humans with similar mutations spontaneously develop autoimmune diseases (IPEX). Resent reports revealed that Foxp3 is expressed in CD4 + CD25 + regulatory T cells (Treg cells), and ectopic expression of Foxp3 in CD4 + Foxp3 - T cells induced a Treg-like phenotype in these cells. Importantly, these reports indicate that Foxp3 is a specific marker for Treg cells. Taken together, Foxp3 is believed to be a crucial regulator of the development and function of Treg cells.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin

Gen-ID: 20371

NCBI Accession: NP_001186276

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation