PSME1 Antikörper

Produktnummer ABIN1449243

Der Maus Monoklonal anti-PSME1 Antikörper (Klon 1G11) (ABIN1449243) detektiert spezifisch PSME1 in WB, IP und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für PSME1 Antikörper (ABIN1449243)

Target: PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PSME1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1G11

Produktdetails anti-PSME1 Antikörper

Spezifität: This antibody detects PA28α on Western blotting, Immunoprecipitation and Immunohistochemistry. Species Reactivity on Western Blot: Human: HeLa, Jurkat, Raji, HL-60, A431, U937, HEL. Mouse: L5178Y, NIH/3T3. Rat: Rat-1.Species Reactivity on Western Blot:

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Immunogen: Recombinant Mouse full length PA28alpha

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2, None, 50 % Glycerol

Konservierungsmittel: Azide free

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu PSME1

Target: PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))

Andere Bezeichnung: PSME1

Hintergrund: PA28, also called 11S regulator, was identified as a proteasome activator that strongly increases the maximal velocity of the hydrolytic reaction and decreases the concentration of substrate required for cleavage by purified 20S proteasomes. It is known that major histocompatibility complex (MHC) class I ligands are mainly produced by the proteasome. PA28 also plays an important role in the processing of MHC class I ligands. However, isolated PA28 does not perform enzymatic activity by itself. PA28 is composed of two homologous subunits, PA28α (30 kDa) and PA28ß. These two subunits assemble into a heterohexamer (α3ß3) or a heteroheptomer (α3ß4 or mixture of α3ß4 and α4ß3). The PA28 complex is expressed constitutively in antigen presenting cells, its expression is upregulated by IFN-γIt appears to be involved in the presentation of endogenous antigen by MHC class I molecules.Synonyms: 11S regulator complex subunit alpha, Activator of multicatalytic protease subunit 1, IFI5111, IGUP I-5111, Interferon gamma up-regulated I-5111 protein, PA28a, PA28alpha, PSME-1, Proteasome activator 28 subunit alpha, Proteasome activator complex subunit 1, REG-alpha

Gen-ID: 5720

NCBI Accession: NP_006254

UniProt: Q06323

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA