CD300a Antikörper

Produktnummer ABIN1449208

Dieser Ratte Monoklonal Antikörper detektiert spezifisch CD300a in FACS. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für CD300a Antikörper (ABIN1449208)

Target: CD300a (CD300A)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD300a Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: TX40

Produktdetails anti-CD300a Antikörper

Spezifität: This antibody reacts with mouse CD300a.

Aufreinigung: Protein G agarose

Immunogen: Mouse MAIR-I transfected Ba/F3 cells

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu CD300a

Target: CD300a (CD300A)

Andere Bezeichnung: CD300A / CMRF35H

Hintergrund: Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Shibuya et al. identified novel paired activated and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domains. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12. MAIR-I is also known as CD300a/ CMRF-35-like Ig-like molecule-8 (CLM-8)/leukocyte mono-Ig-like receptor 1 (LMIR1). MAIR-II is also known as CD300d/LMIR2/CLM-4/dendritic cell-derived Ig-like receptor 1 (DIgR1).Synonyms: CD300 antigen-like family member A, CLM-8, CMRF-35-H9, CMRF35-H, CMRF35-H9, CMRF35-like molecule 8, IRC1/IRC2, IRp60, Inhibitory receptor protein 60, NK inhibitory receptor

Gen-ID: 217303

NCBI Accession: NP_739564

UniProt: Q6SJQ0

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process