RAN Antikörper

Produktnummer ABIN1449197

Der Maus Monoklonal Anti-RAN-Antikörper wurde für WB, IF und IP validiert. Er ist geeignet, RAN in Proben von Human, Maus, Ratte und Hamster zu detektieren.

Kurzübersicht für RAN Antikörper (ABIN1449197)

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Reaktivität: Human, Maus, Ratte, Hamster

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RAN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: ARAN1

Produktdetails anti-RAN Antikörper

Spezifität: This antibody reacts with Ran. ARAN1 inhibits the basic type NLS-dependent nuclear protein import. ARAN1 recognizes an epitope located the residues between 207 and 216 of human Ran.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat, Hamster

Aufreinigung: Protein A agarose

Immunogen: Recombinant human Ran

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu RAN

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Andere Bezeichnung: RAN

Hintergrund: The Ran GTPase has important roles in nucleocytoplasmic transport, cell cycle progression, nuclear organization and nuclear envelope (NE) assembly. The small GTPase Ran is essential for spindle assembly. Ran is proposed to act through its nuclear import receptors importin and/or importin to control the sequestration of proteins necessary for spindle assembly. Ran, is required for coordinating the onset of mitosis with S-phase completion in mammalian cells. Other defects in the Ran-GTPase network also result in disruption of cell-cycle processes such as DNA replication, exit from mitosis and, at least in budding yeast, accurate chromosome segregation.Synonyms: ARA24, Androgen receptor-associated protein 24, GTP-binding nuclear protein Ran, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein

Molekulargewicht: 25 kDa

Gen-ID: 5901

NCBI Accession: NP_006316

UniProt: P62826

Pathways: Regulatorische RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus