Cullin 7 Antikörper (PE)

Produktnummer ABIN1434567

Dieses Anti-Cullin 7-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cullin 7 in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh) und Hund.

Kurzübersicht für Cullin 7 Antikörper (PE) (ABIN1434567)

Target: Cullin 7 (CUL7)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cullin 7 Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB)

Produktdetails anti-Cullin 7 Antikörper (PE)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Cullin 7

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Cullin 7

Target: Cullin 7 (CUL7)

Andere Bezeichnung: Cullin 7

Hintergrund:

Synonyms: CUL-7, CUL7, CUL7_HUMAN, Cullin-7, dJ20C7.5, KIAA0076.

Background: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity.Involvement in disease: Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.

Molekulargewicht: 191kDa

Gen-ID: 9820

Pathways: ER-Nucleus Signaling