HLA-B27 Antikörper (PE-Cy5)

Produktnummer ABIN1433729

Der Kaninchen Polyklonal Anti-HLA-B27-Antikörper wurde für WB validiert. Er ist geeignet, HLA-B27 in Proben von Human zu detektieren.

Kurzübersicht für HLA-B27 Antikörper (PE-Cy5) (ABIN1433729)

Target: HLA-B27 (HLA Class I Histocompatibility Antigen, B-27 alpha Chain (HLA-B27))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-B27 Antikörper ist konjugiert mit PE-Cy5

Applikation: Western Blotting (WB)

Produktdetails anti-HLA-B27 Antikörper (PE-Cy5)

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HLA B27

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu HLA-B27

Target: HLA-B27 (HLA Class I Histocompatibility Antigen, B-27 alpha Chain (HLA-B27))

Andere Bezeichnung: HLA B27

Hintergrund:

Synonyms: HLA B27 HLA-B27, HLAB, Leukocyte antigen class I B, Lymphocyte antigen, Major histocompatibility complex class I B, SPDA1, 1B27_HUMAN.

Background: Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind peptides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B encodes a membrane anchored heavy chain which hetero-dimerizes with a light chain (-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B alleles. The HLA-B27 allele appears with increased frequency in uveitis patients.

Molekulargewicht: 38kDa

Pathways: Human Leukocyte Antigen (HLA) in Adaptive Immune Response