UNC5A Antikörper (PE)

Produktnummer ABIN1426760

Der Kaninchen Polyklonal anti-UNC5A Antikörper wird verwendet zum Nachweis von UNC5A in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für UNC5A Antikörper (PE) (ABIN1426760)

Target: UNC5A (Unc-5 Homolog A (UNC5A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNC5A Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-UNC5A Antikörper (PE)

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Unc5a

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM: 1:20-100
Optimal working dilution should be determined by the investigator.

Kommentare:

Exitation/Emission: 480,565nm/578nm

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at 4 °C

Haltbarkeit: 12 months

Details zu UNC5A

Target: UNC5A (Unc-5 Homolog A (UNC5A))

Andere Bezeichnung: Unc5a/Unc5h1

Hintergrund:

The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

Subcellular location: Extracellular

Synonyms: Netrin receptor UNC 5A, Netrin receptor UNC5A, Netrin receptor Unc5h1, Protein unc-5 homolog 1, Protein unc-5 homolog A, Unc 5 homolog 1, Unc 5 homolog A, Unc 5a, Unc5 a, Unc5 homolog 1, Unc5 homolog A, Unc5a, UNC5A_HUMAN, Unc5h1, FLJ16449, KIAA1976.