NGEF Antikörper (PE-Cy5.5)
Kurzübersicht für NGEF Antikörper (PE-Cy5.5) (ABIN1426588)
Target
Alle NGEF Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Kreuzreaktivität
- Maus, Ratte
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Homologie
- Human,Dog,Cow,Pig,Horse,Chicken
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human EPHEXIN
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Isotyp
- IgG
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Applikationshinweise
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FCM(1:100-500)
Optimal working dilution should be determined by the investigator. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Haltbarkeit
- 12 months
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- NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
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Andere Bezeichnung
- Ephexin-1/EPHEXIN
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Hintergrund
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Synonyms: EPHEXIN, ARHGEF27, Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF
Background: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
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Molekulargewicht
- 82kDa
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Gen-ID
- 25791
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UniProt
- Q8N5V2
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Pathways
- Neurotrophin Signalübertragung
Target
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