DSCAM Antikörper (PE)

Produktnummer ABIN1426575

Dieses Anti-DSCAM-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DSCAM in FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für DSCAM Antikörper (PE) (ABIN1426575)

Target: DSCAM (Down Syndrome Cell Adhesion Molecule (DSCAM))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DSCAM Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-DSCAM Antikörper (PE)

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Dscam

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM: 1:20-100
Optimal working dilution should be determined by the investigator.

Kommentare:

Exitation/Emission: 480,565nm/578nm

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at 4 °C

Haltbarkeit: 12 months

Details zu DSCAM

Target: DSCAM (Down Syndrome Cell Adhesion Molecule (DSCAM))

Andere Bezeichnung: Dscam

Hintergrund:

DSCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is predominantly expressed in brain and contains six Fibronectin type-III domains and ten Ig-like C2-type domains. In mice, DSCAM is responsible for regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). In some cell types, DSCAM also mediates heteroneuronal self-avoidance, which is important for the regular spacing of cell bodies and the prevention of hyperfasciculation. In humans, two DSCAM isoforms exist due to alternative splicing. The long isoform (also known as CHD2-42) is a single pass type I membrane protein, while the short isoform (CHD2-52), which lacks the C-terminal transmembrane containing region (amino acids 1572-2012), is secreted.

Subcellular location: Extracellular

Synonyms: CHD2 42, CHD2 52, CHD2, Down syndrome cell adhesion molecule, DSCAM, DSCAM_HUMAN, human CHD2-52 down syndrome cell adhesion molecule 2, 9, OTTHUMP00000109193 2, SD11109p.

Pathways: Regulation of Cell Size