UVRAG Antikörper (Cy3)

Produktnummer ABIN1423331

Produktdetails anti-UVRAG Antikörper (Cy3)

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UVRAG Antikörper ist konjugiert mit Cy3

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UVRAG/DHTX

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu UVRAG

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Andere Bezeichnung: UVRAG (UVRAG Produkte)

Synonyme: DHTX antikoerper, VPS38 antikoerper, p63 antikoerper, 9530039D02Rik antikoerper, AI648770 antikoerper, BB124205 antikoerper, Uvrag1 antikoerper, Uvragl antikoerper, zgc:56164 antikoerper, uvrag antikoerper, MGC81810 antikoerper, UVRAG antikoerper, MGC131135 antikoerper, CG6116 antikoerper, Dmel\\CG6116 antikoerper, UV radiation resistance associated antikoerper, UV radiation resistance associated gene antikoerper, UV radiation resistance associated S homeolog antikoerper, UV radiation resistance associated L homeolog antikoerper, UV-resistance associated gene antikoerper, UVRAG antikoerper, Uvrag antikoerper, uvrag antikoerper, uvrag.S antikoerper, uvrag.L antikoerper

Hintergrund:

Synonyms: DHTX, Disrupted in heterotaxy, p63, UV radiation resistance associated, UV radiation resistance associated gene, UV radiation resistance associated gene protein, UV radiation resistance-associated gene protein, UVRAG, UVRAG_HUMAN.

Background: UVRAG, also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Ubiquitously expressed, UVRAG is found at highest levels in kidney, lung, liver and brain. UVRAG contains one C2 domain, which is thought to be involved in calcium-dependent phospholipid binding.

Gen-ID: 7405