Biogenesis of Lysosome-Related Organelles Complex 1 Subunit 6 (BLOC1S6) Antikörper (Cy5.5)

Produktnummer ABIN1422823

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Biogenesis of Lysosome-Related Organelles Complex 1 Subunit 6 in WB und IF (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Biogenesis of Lysosome-Related Organelles Complex 1 Subunit 6 (BLOC1S6) Antikörper (Cy5.5) (ABIN1422823)

Target: Biogenesis of Lysosome-Related Organelles Complex 1 Subunit 6 (BLOC1S6)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Cy5.5

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails

Verwendungszweck: C17orf59 Polyclonal Antibody, Cy5.5 Conjugated

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C17orf59

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:100-500), IF(IHC-P)(1:50-200)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Biogenesis of Lysosome-Related Organelles Complex 1 Subunit 6 (BLOC1S6)

Andere Bezeichnung: C17orf59

Hintergrund:

Synonyms: Chromosome 17 open reading frame 59, CQ059_HUMAN, FLJ20014, PRO2472, Uncharacterized protein C17orf59.

Background: C17orf59 is a 357 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Gen-ID: 54785