NSG1 Antikörper (AA 1-100) (Cy5)

Produktnummer ABIN1415874

Dieses Anti-NSG1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NSG1 in WB, IF (cc) und IF (p). Geeignet für Maus und Affe.

Kurzübersicht für NSG1 Antikörper (AA 1-100) (Cy5) (ABIN1415874)

Target: NSG1 (D4S234E) (Neuron-Specific Protein Family Member 1 (D4S234E))

Reaktivität: Maus, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSG1 Antikörper ist konjugiert mit Cy5

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-NSG1 Antikörper (Cy5)

Bindungsspezifität: AA 1-100

Kreuzreaktivität: Affe, Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NEEP21

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu NSG1

Target: NSG1 (D4S234E) (Neuron-Specific Protein Family Member 1 (D4S234E))

Andere Bezeichnung: NEEP21

Hintergrund:

Synonyms: neuron-enriched endosomal 21 kDa protein, NSG1_HUMAN.

Background: NEEP21, also known as Brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (neurotensin receptor 2).