MAP1LC3A/B Antikörper (AA 25-121) (Cy7)

Produktnummer ABIN1414087

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAP1LC3A/B in FACS. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für MAP1LC3A/B Antikörper (AA 25-121) (Cy7) (ABIN1414087)

Target: MAP1LC3A/B (MAP1LC3A,B)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP1LC3A/B Antikörper ist konjugiert mit Cy7

Applikation: Flow Cytometry (FACS)

Produktdetails anti-MAP1LC3A/B Antikörper (Cy7)

Bindungsspezifität: AA 25-121

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MAP LC3 Alpha

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MAP1LC3A/B

Target: MAP1LC3A/B (MAP1LC3A,B)

Andere Bezeichnung: MAP 1A/1B LC3 Alpha/Beta

Hintergrund:

Synonyms: Microtubule-associated proteins 1A/B light chain 3A, Microtubule-associated proteins 1A/B light chain 3B, Microtubule-associated proteins 1Beta light chain 3A, Microtubule-associated proteins 1Beta light chain 3A, MAP1B LC3 A, MAP LC3 Beta, MAP-LC3 Beta, MAP1 light chain 3-like protein 1.MAP1LC3B.MLP3A_HUMAN

Background: Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3 Beta) and MAP-light chain 3 alpha (MAP-LC3 alpha) are subunits of both MAP1A and MAP1B. MAP-LC3M Beta, a homolog of Apg8p, is essential for autophagy and associated to the autophagosome membranes after processing. Two forms of LC3 Beta, the cytosolic LC3-I and the membrane-bound LC3-II, are produced post-translationally. LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3, followed by the conversion of a fraction of LC3-I into LC3-II. LC3 enhances fibronectin mRNA translation in ductus arteriosus cells through association with 60S ribosomes and binding to an AU-rich element in the 3? untranslated region of fibronectin mRNA. This facilitates sorting of fibronectin mRNA onto rough endoplasmic reticulum and translation. MAP LC3 Beta may also be involved in formation of autophagosomal vacuoles. It is expressed primarily in heart, testis, brain and skeletal muscle.

Gen-ID: 54901, 84557

UniProt: Q9H492, Q9GZQ8