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TIMM8A/DDP Antikörper (AA 31-97) (Cy5)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TIMM8A/DDP in IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN1411102

Kurzübersicht für TIMM8A/DDP Antikörper (AA 31-97) (Cy5) (ABIN1411102)

Target

Alle TIMM8A/DDP (TIMM8A) Antikörper anzeigen
TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

Reaktivität

  • 35
  • 11
  • 10
  • 1
  • 1
  • 1
Human

Wirt

  • 30
  • 5
Kaninchen

Klonalität

  • 32
  • 3
Polyklonal

Konjugat

  • 15
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TIMM8A/DDP Antikörper ist konjugiert mit Cy5

Applikation

  • 12
  • 12
  • 12
  • 10
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 31-97

    Homologie

    Human,Mouse,Rat,Cow,Sheep,Pig

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human TIMM8A

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

    Andere Bezeichnung

    TIMM8A

    Hintergrund

    Synonyms: DDP 1, DDP, DDP1, Deafness dystonia protein 1, Deafness/dystonia peptide, DFN 1, DFN1, MGC12262, Mitochondrial import inner membrane translocase subunit Tim8 A, MTS, TIM 8A, TIM8A, TIMM 8A, Translocase of inner mitochondrial membrane 8 homolog A, X linked deafness dystonia protein, TIM8A_HUMAN.

    Background: The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).

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