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PRND Antikörper (AA 51-120) (Cy7)

Dieses Anti-PRND-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PRND in WB, IF (cc) und IF (p). Geeignet für Human.
Produktnummer ABIN1410894

Kurzübersicht für PRND Antikörper (AA 51-120) (Cy7) (ABIN1410894)

Target

Alle PRND Antikörper anzeigen
PRND (Prion Protein 2 (Dublet) (PRND))

Reaktivität

  • 18
  • 3
  • 1
Human

Wirt

  • 19
Kaninchen

Klonalität

  • 19
Polyklonal

Konjugat

  • 6
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PRND Antikörper ist konjugiert mit Cy7

Applikation

  • 19
  • 12
  • 12
  • 7
  • 3
  • 3
  • 3
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 3
    AA 51-120

    Homologie

    Human,Mouse,Rat,Cow,Pig

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Doppel

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    PRND (Prion Protein 2 (Dublet) (PRND))

    Andere Bezeichnung

    Doppel/DPL

    Hintergrund

    Synonyms: DPL, Dublet, MGC41841, Prion gene complex downstream, Prion like protein doppel, Prion protein 2 dublet, Prion protein 2, Prion-like protein doppel, PRND, PRND_HUMAN, PrPLP.

    Background: Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, including scrapie in sheep, BSE in cattle, and Cruetzfeldt-Jacob disease in humans. The PRND gene locus, located on human chromosome 20p, encodes for the doppel protein (Dpl), which exhibits approximately 25 % sequence homology with PrP. Dpl is characterized by an alpha-helical conformation, intramolecular disulfide bonds, and two N-linked oligosaccharides, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor. Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice. Dpl does not appear to contribute to prion disease progression, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice. Dpl is also thought to play a role in angiogenesis, specifically maturation of the blood-brain barrier.

    Pathways

    Transition Metal Ion Homeostasis
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