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FEZF1 Antikörper (AA 199-280) (Cy3)

This anti-FEZF1 antibody (ABIN1409511) is a Rabbit Polyclonal antibody detecting FEZF1 in IF (cc), IF (p). Suitable for Human.
Produktnummer ABIN1409511

Quick Overview for FEZF1 Antikörper (AA 199-280) (Cy3) (ABIN1409511)

Target

Alle FEZF1 Antikörper anzeigen
FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

Reaktivität

  • 34
  • 11
  • 2
  • 2
  • 2
  • 1
Human

Wirt

  • 34
Kaninchen

Klonalität

  • 34
Polyklonal

Konjugat

  • 13
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FEZF1 Antikörper ist konjugiert mit Cy3

Applikation

  • 17
  • 16
  • 12
  • 12
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 10
    • 5
    • 3
    • 2
    • 1
    • 1
    AA 199-280

    Homologie

    Human,Mouse,Rat,Cow,Sheep,Pig,Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human ZNF312B

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

    Andere Bezeichnung

    ZNF312B/FEZF1

    Hintergrund

    Synonyms: FEZ, FEZ family zinc finger 1, Fez family zinc finger protein 1, fez like, fezf1, FEZF1_HUMAN, Zinc finger protein 312 like, Zinc finger protein 312B.

    Background: Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.

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