Utrophin Antikörper (Cy5)

Produktnummer ABIN1408906

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Utrophin in FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Utrophin Antikörper (Cy5) (ABIN1408906)

Target: Utrophin (UTRN)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Utrophin Antikörper ist konjugiert mit Cy5

Applikation: Flow Cytometry (FACS)

Produktdetails anti-Utrophin Antikörper (Cy5)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Utrophin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Utrophin

Target: Utrophin (UTRN)

Andere Bezeichnung: Utrophin

Hintergrund:

Synonyms: DMDL, DRP 1, DRP, DRP-1, DRP1, Dystrophin like protein, Dystrophin related protein 1, Dystrophin related protein, Dystrophin-related protein 1, FLJ23678, UTRN, UTRO_HUMAN, Utrophin homologous to dystrophin, Utrophin

Background: Dystrophin and utrophin are related structural, Actin-binding proteins that are involved in anchoring the cytoskeleton to the plasma membrane. Dystrophin is the protein product of the Duchenne/Becker muscular dystrophy gene. Dystrophin expression is found in muscle and brain tissues, where it is localized to the inner surface of the plasma membrane. It has been speculated that alternative splicing of the carboxy terminus allows dystrophin to interact with a variety of proteins. Research has shown that the loss of dystrophin-associated proteins in Duchenne afflicted muscle is due to the absence of dystrophin rather than to muscle degradation and that the lack of dystrophin results in the loss of linkage between the cytoskeleton and the extracellular matrix. Evidence suggests that the upregulation of utrophin can reduce the dystrophic pathology.

Gen-ID: 7402

Pathways: Skeletal Muscle Fiber Development