FKBP5 Antikörper (Cy3)

Produktnummer ABIN1408155

Dieses Anti-FKBP5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FKBP5 in IF (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für FKBP5 Antikörper (Cy3) (ABIN1408155)

Target: FKBP5 (FK506 Binding Protein 5 (FKBP5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FKBP5 Antikörper ist konjugiert mit Cy3

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-FKBP5 Antikörper (Cy3)

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FKBP51

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 4°C

Haltbarkeit: 12 months

Details zu FKBP5

Target: FKBP5 (FK506 Binding Protein 5 (FKBP5))

Andere Bezeichnung: Fkbp51

Hintergrund:

The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin (1). Several related immunophilins, FKBP12, FKBP51 and FKBP52, are characterized as cytosolic FK506-binding proteins, and following ligand binding, they functionally inhibit the phosphatase activity of calcineurin (2,3). The ubiquitously expressed FKBP12 also associates with the cytoplasmic domain of the TGF?type I receptor, where it stabilizes the inactive conformation of the receptor and blocks the activation of the TGF?pathway (4). FKBP51 and FKBP52 are two highly related proteins (5,6). FKBP51 is predominantly expressed in T cells and is induced by glucocorticoids (5). FKBP51 mediates the effects of FK506 and rapamycin by inhibiting intracellular calcineurin activity, and by blocking T-cell activation and proliferation (7). FKBP52, known also as FKBP-59 or heat shock protein 56, is expressed in a variety of tissues and can also associate with the heat shock protein (hsp90) in mature steroid receptor complexes (6,8).

Synonyms: FKBP 5, FKBP 51, FKBP 54, FKBP-5, FKBP-51, FKBP5, FKBP5_HUMAN, FKBP54, HSP90 binding immunophilin, HSP90-binding immunophilin, P54 antibody Peptidyl prolyl cis trans isomerase, Peptidyl-prolyl cis-trans isomerase FKBP5, Peptidylprolyl cis trans isomerase, PPIase, PPIase FKBP5, Ptg 10, Ptg10, Rotamase, T cell FK506 binding protein, 51 kDa FK506 binding protein 5, 51 kDa FK506 binding protein, 51 kDa FK506-binding protein, 51 kDa FKBP, 54 kDa progesterone receptor associated immunophilin, 54 kDa progesterone receptor-associated immunophilin, AIG 6, AIG6, Androgen regulated protein 6, Androgen-regulated protein 6, FF1 antigen, FK506 binding protein 5, FK506-binding protein 5, MGC111006, OTTHUMP00000016268.