GOPC Antikörper (AA 131-230) (Cy5.5)

Produktnummer ABIN1408067

Der Kaninchen Polyklonal Anti-GOPC-Antikörper wurde für IF (cc) und IF (p) validiert. Er ist geeignet, GOPC in Proben von Human zu detektieren.

Kurzübersicht für GOPC Antikörper (AA 131-230) (Cy5.5) (ABIN1408067)

Target: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GOPC Antikörper ist konjugiert mit Cy5.5

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-GOPC Antikörper (Cy5.5)

Bindungsspezifität: AA 131-230

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PIST

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GOPC

Target: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Andere Bezeichnung: PIST/GOPC

Hintergrund:

Synonyms: CAL, CFTR associated ligand, CFTR-associated ligand, FIG, Fused in glioblastoma, Golgi associated PDZ and coiled coil mot containing, Golgi associated PDZ and coiled coil mot containing protein, Golgi-associated PDZ and coiled-coil mot-containing protein, GOPC, GOPC_HUMAN, GOPC1, OTTHUMP00000040403, PDZ protein interacting specically with TC 10, PDZ protein interacting specically with TC10, PDZ/coiled coil domain binding partner for the rho family GTPase TC 10, PDZ/coiled coil domain binding partner for the rho family GTPase TC10, PIST, Protein interacting specically with Tc 10, Protein interacting specically with Tc10, dJ94G16.2, dJ94G16.2 PIST.

Background: PIST (PDZ protein interacting specifically with TC10), also known as GOPC (golgi associated PDZ and coiled-coil motif containing), CAL or FIG, is a 462 amino acid protein that localizes to the cytoplasm, as well as to the membrane of the golgi apparatus and to the cell junction. Expressed ubiquitously and containing one PDZ (DHR) domain, PIST functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, PIST is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding PIST are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis. Three isoforms of PIST exist due to alternative splicing events.

Pathways: Maintenance of Protein Location, Asymmetric Protein Localization