UVRAG Antikörper (AbBy Fluor® 488)

Produktnummer ABIN1405462

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch UVRAG in WB und IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für UVRAG Antikörper (AbBy Fluor® 488) (ABIN1405462)

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UVRAG Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-UVRAG Antikörper (AbBy Fluor® 488)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UVRAG/DHTX

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu UVRAG

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Andere Bezeichnung: UVRAG

Hintergrund:

Synonyms: DHTX, Disrupted in heterotaxy, p63, UV radiation resistance associated, UV radiation resistance associated gene, UV radiation resistance associated gene protein, UV radiation resistance-associated gene protein, UVRAG, UVRAG_HUMAN.

Background: UVRAG, also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Ubiquitously expressed, UVRAG is found at highest levels in kidney, lung, liver and brain. UVRAG contains one C2 domain, which is thought to be involved in calcium-dependent phospholipid binding.

Gen-ID: 7405