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MYLK2 Antikörper (AbBy Fluor® 488)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MYLK2 in WB und IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN1405120

Kurzübersicht für MYLK2 Antikörper (AbBy Fluor® 488) (ABIN1405120)

Target

Alle MYLK2 Antikörper anzeigen
MYLK2 (Myosin Light Chain Kinase 2 (MYLK2))

Reaktivität

Human, Maus, Ratte

Wirt

  • 33
  • 3
Kaninchen

Klonalität

  • 35
  • 1
Polyklonal

Konjugat

  • 17
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MYLK2 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation

  • 30
  • 12
  • 8
  • 7
  • 7
  • 5
  • 4
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human MYLK2

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    MYLK2 (Myosin Light Chain Kinase 2 (MYLK2))

    Andere Bezeichnung

    MYLK2

    Hintergrund

    Synonyms: KMLC, MLCK, MLCK2, MYLK 2, Myosin light chain kinase 2, Myosin light chain kinase 2 skeletal muscle, Myosin light chain kinase 2 skeletal/cardiac muscle, Skeletal muscle myosin light chain kinase, Skeletal myosin light chain kinase, skMLCK, MYLK2_HUMAN.

    Background: The Ca2+/calmodulin-dependent protein kinases (CaM kinases) are a structurally related subfamily of serine/threonine kinases that includes CaMKI, CaMKII, CaMKIV and myosin light chain kinases (MYLK, also designated MLCK). The MYLK kinases phosphorylate myosin regulatory light chains to catalyze myosin interaction with actin filaments resulting in contractile activity. Non-muscle, smooth muscle and skeletal/cardiac muscle MYLK isoforms exist. The MYLK gene (also designated MYLK1) encodes both smooth muscle and non-muscle isoforms as well as telokin, a small C-terminal isoform expressed only in smooth muscle with the capacity to stabilize unphosphorylated myosin filaments. Multiple transcript variants are described for the MYLK gene. Smooth-muscle and non-muscle MYLK isoforms are expressed in a wide variety of adult and fetal tissues. The skeletal/cardiac muscle isoforms of MYLK are encoded by a separate gene, MYLK2 (also designated skMLCK). MYLK appears to be a target for PAKs (p21-activated kinases). PAK1 interaction with MYLK results in a decrease in MYLK activity and myosin light chain phosphorylation.

    Gen-ID

    85366

    Pathways

    Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation
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