HCN3 Antikörper (Biotin)

Produktnummer ABIN1405063

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch HCN3 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Maus, Ratte und Human.

Kurzübersicht für HCN3 Antikörper (Biotin) (ABIN1405063)

Target: HCN3 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3))

Reaktivität: Maus, Ratte, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HCN3 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HCN3 Antikörper (Biotin)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HCN3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu HCN3

Target: HCN3 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3))

Andere Bezeichnung: HCN3

Hintergrund:

Synonyms: Hcn3, HCN3_HUMAN, hyperpolarization activated cyclic nucleotide-gated potassium channel 3, KIAA1535, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

Background: Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1-4), each with a core transmembrane segment domain and a C-terminal 120 amino-acid cyclic nucleotide-binding domain motif. HCN channels are expressed in the brain, heart, thalamus and testis. The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart. HCN3 contains a segment characterized by a series of positively charged amino acids at every third position. This region designated S4 is likely to be the voltage sensor of the protein. In the brain, HCN3 and HCN4 exhibit subcortical distribution mainly concentrated in the hypothalamus and thalamus, respectively.

Gen-ID: 57657