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MIS18 Binding Protein 1 (MIS18BP1) Antikörper (Biotin)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN1403665

Kurzübersicht für MIS18 Binding Protein 1 (MIS18BP1) Antikörper (Biotin) (ABIN1403665)

Target

Alle MIS18 Binding Protein 1 (MIS18BP1) Antikörper anzeigen
MIS18 Binding Protein 1 (MIS18BP1)

Reaktivität

  • 18
  • 14
  • 14
  • 1
Human, Maus, Ratte

Wirt

  • 16
  • 2
Kaninchen

Klonalität

  • 18
Polyklonal

Konjugat

  • 5
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Biotin

Applikation

  • 18
  • 13
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human KNL2/C14orf106

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    MIS18 Binding Protein 1 (MIS18BP1)

    Andere Bezeichnung

    C14orf106

    Hintergrund

    Synonyms: Chromosome 14 open reading frame 106, HsKNL-2, KIAA1903, Kinetochore-associated protein KNL-2 homolog, M18BP1, Mis18-binding protein 1, MIS18BP1, P243, Putative protein p243 which interacts with transcription factor Sp1, Uncharacterized potential DNA binding protein C14orf106, M18BP_HUMAN.

    Background: C14orf106 is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It interacts with SP1. There are two isoforms.Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5 % of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14,19) translocations found in a variety of B cell malignancies. The C14orf106 gene product has been provisionally designated C14orf106 pending further characterization.

    Pathways

    Chromatin Binding
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