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SHARPIN Antikörper (AA 260-310) (Biotin)

This anti-SHARPIN antibody (ABIN1403515) is a Rabbit Polyclonal antibody detecting SHARPIN in WB, IHC (p). Suitable for Human, Rat, Mouse.
Produktnummer ABIN1403515

Kurzübersicht für SHARPIN Antikörper (AA 260-310) (Biotin) (ABIN1403515)

Target

Alle SHARPIN Antikörper anzeigen
SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

Reaktivität

  • 42
  • 24
  • 19
  • 2
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 39
  • 3
Kaninchen

Klonalität

  • 41
  • 1
Polyklonal

Konjugat

  • 20
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SHARPIN Antikörper ist konjugiert mit Biotin

Applikation

  • 38
  • 15
  • 13
  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 14
    • 7
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 260-310

    Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human SHARPIN

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

    Andere Bezeichnung

    SHARPIN

    Hintergrund

    Synonyms: SIPL1, Sharpin, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, hSIPL1, PSEC0216

    Background: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

    Gen-ID

    81858

    UniProt

    Q9H0F6
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