ALAS1 Antikörper (Biotin)

Produktnummer ABIN1403245

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ALAS1 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für ALAS1 Antikörper (Biotin) (ABIN1403245)

Target: ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALAS1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ALAS1 Antikörper (Biotin)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ALAS1/ALAS-H

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu ALAS1

Target: ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))

Andere Bezeichnung: ALAS1

Hintergrund:

Synonyms: mitochondrial, nonspecic, 5 aminolevulinate synthase, 5 aminolevulinate synthase nonspecic mitochondrial, 5 aminolevulinic acid synthase, 5-aminolevulinate synthase, 5-aminolevulinic acid synthase 1, Alas 1, ALAS 3, ALAS, ALAS H, ALAS N, ALAS-H, alaS1, ALAS3, ALASH, Aminolevulinate delta synthase 1, Aminolevulinic acid synthase 1, Delta ALA synthetase, Delta aminolevulinate synthase, Delta-ALA synthase 1, Delta-aminolevulinate synthase 1, HEM1_HUMAN, MIG 4, MIG4, Migration inducing protein 4.

Background: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

Gen-ID: 211

Pathways: Regulation of Lipid Metabolism by PPARalpha