MEF2B Antikörper (AbBy Fluor® 555)

Produktnummer ABIN1402901

Der Kaninchen Polyklonal Anti-MEF2B-Antikörper wurde für WB und IF (p) validiert. Er ist geeignet, MEF2B in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für MEF2B Antikörper (AbBy Fluor® 555) (ABIN1402901)

Target: MEF2B (Myocyte Enhancer Factor 2B (MEF2B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEF2B Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-MEF2B Antikörper (AbBy Fluor® 555)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MEF2B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MEF2B

Target: MEF2B (Myocyte Enhancer Factor 2B (MEF2B))

Andere Bezeichnung: MEF2B

Hintergrund:

Synonyms: PRDM3, MADS box transcription enhancer factor 2, MDS1 EVI1, Mef2b, MEF2B_HUMAN, MEF-2B, myocyte enhancer factor 2B, myocyte specic enhancer factor 2B, Myocyte-specic enhancer factor 2B, RSRFR2, serum response factor like protein 2, Serum response factor-like protein 2, XMEF2.

Background: The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four family members, termed MEF-2A, -2B, -2C, and -2D, arise from alternatively spliced transcripts. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5, and MRF4, are one class of identified factors. The MEF-2 family represents a second class of DNA binding regulatory proteins. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.