PYGB Antikörper (AbBy Fluor® 488)

Produktnummer ABIN1402798

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PYGB in IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für PYGB Antikörper (AbBy Fluor® 488) (ABIN1402798)

Target: PYGB (GPBB) (phosphorylase, Glycogen, Brain (GPBB))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PYGB Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-PYGB Antikörper (AbBy Fluor® 488)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GPBB/PYGB

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu PYGB

Target: PYGB (GPBB) (phosphorylase, Glycogen, Brain (GPBB))

Andere Bezeichnung: GPBB

Hintergrund:

Synonyms: Brain glycogen phosphorylase, Glycogen phosphorylase B, Glycogen phosphorylase brain form, Glycogen Phosphorylase Isoenzyme BB, Glycogen phosphorylase, brain form, MGC9213, Phosphorylase glycogen brain, PYGB, PYGB_HUMAN.

Background: Glycolysis is an evolutionarily conserved series of ten chemical reactions that utilizes eleven enzymes to concomitantly generate pyruvate and ATP from glucose. fructose kinase-2/fructose 2,6-bisphosphatase (PFK-2) stimulates the synthesis and degradation of fructose 2,6-bisphosphate. Glycogen phosphorylase (also known as GP) is an allosteric enzyme important in carbohydrate metabolism. Its activity is regulated through either noncovalent binding of metabolites or by covalent modification. Glycogen phosphorylase catalyzes the phosphorylation of glycogen to Glc-1-P. There are three genes which encode the brain, liver and muscle forms of glycogen phosphorylase, PYGB, PYGL and PYGM. Because of its fundamental role in the metabolism of glycogen, glycogen phosphorylase has been a target for the design of inhibitory compounds, which could be valuable in the therapeutic treatment of type 2 diabetes mellitus.

Gen-ID: 5834

Pathways: Cellular Glucan Metabolic Process