Dieses Anti-Dihydrofolate Reductase-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Dihydrofolate Reductase in IF (p) und FACS. Geeignet für Human.
Produktnummer ABIN1400592
Kurzübersicht für Dihydrofolate Reductase Antikörper (AbBy Fluor® 647) (ABIN1400592)
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store at 4 °C for 12 months
Haltbarkeit
12 months
Target
Dihydrofolate Reductase (DHFR)
Andere Bezeichnung
DHFR
Hintergrund
DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and is a crucial enzyme for the synthesis of purines, pyrimidines and some amino acids. Inhibition of the activity of this enzyme leads to arrest of DNA synthesis and cell death. Gene expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.