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DR1 Antikörper (AbBy Fluor® 647)

This anti-DR1 antibody (ABIN1400574) is a Rabbit Polyclonal antibody detecting DR1 in WB, IF (p). Suitable for Human, Mouse, Rat.
Produktnummer ABIN1400574

Kurzübersicht für DR1 Antikörper (AbBy Fluor® 647) (ABIN1400574)

Target

Alle DR1 Antikörper anzeigen
DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Reaktivität

  • 49
  • 36
  • 29
  • 10
  • 8
  • 7
  • 5
  • 5
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
Human, Maus, Ratte

Wirt

  • 47
  • 2
Kaninchen

Klonalität

  • 49
Polyklonal

Konjugat

  • 21
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DR1 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation

  • 42
  • 13
  • 12
  • 7
  • 6
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human DR1 protein

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

    Andere Bezeichnung

    DR1 protein

    Hintergrund

    Synonyms: Dr1 protein; NC2; Negative cofactor 2 beta; Down regulator of transcription 1; Down regulator of transcription 1 TBP binding; Down-regulator of transcription 1; DR 1; Dr1; NC 2; NC2 beta; NC2-beta; NC2B_HUMAN; Negative co factor 2; Negative cofactor 2; Negative cofactor 2-beta; Protein Dr1; TATA binding protein associated phosphoprotein; TATA-binding protein-associated phosphoprotein.

    Background: DR1, also known as NC2 (negative cofactor 2 subunit ), is a TFIID (TATA box-binding protein)-associated protein. DR1 localizes to the nucleus and contains an N-terminal histone fold motif, a TFIID-binding domain and an alanine and glutamine rich region. Via its histone fold motif, DR1 forms a heterodimer with NC2å (DRAP1) to comprise the conserved eukaryotic complex, NC2 (negative cofactor 2). The NC2 complex can both positively and negatively regulate transcription by RNA Pol II. More specifically, NC2 acts as a repressor of TATA-dependent transcription and acts as an activator for DPE-dependent transcription. NC2 represses RNA Pol II transcription by binding to TFIID and inhibiting association of the transcription factors TFIIA and TFIIB. NC2 activity is regulated by phosphorylation. Both subunits, NC2å and DR1, are phosphorylated in vivo.

    Gen-ID

    10589
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