HEXDC Antikörper (AA 1-100) (AbBy Fluor® 647)

Produktnummer ABIN1398972

Dieses Anti-HEXDC-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HEXDC in WB, IF (cc) und IF (p). Geeignet für Human.

Kurzübersicht für HEXDC Antikörper (AA 1-100) (AbBy Fluor® 647) (ABIN1398972)

Target: HEXDC (Hexosaminidase D (HEXDC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HEXDC Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-HEXDC Antikörper (AbBy Fluor® 647)

Bindungsspezifität: AA 1-100

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HEXDC

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu HEXDC

Target: HEXDC (Hexosaminidase D (HEXDC))

Andere Bezeichnung: HEXDC

Hintergrund:

Synonyms: Beta hexosaminidase D, Beta N acetylhexosaminidase, FLJ23825, Hexosaminidase glycosyl hydrolase family 20 catalytic domain containing, hexosaminidase glycosyl hydrolase family 20, catalytic domain, Hexosaminidase D, Hexosaminidase domain containing protein, N acetyl beta galactosaminidase, HEXDC_HUMAN.

Background: HEXDC, also known as hexosaminidase D, beta-hexosaminidase D, N-acetyl-beta-galactosaminidase, hexosaminidase domain-containing protein or beta-N-acetylhexosaminidase, is a 486 amino acid cytoplasmic and nuclear protein that has hexosaminidase activity and belongs to the glycosyl hydrolase 20 family. Existing as two alternatively spliced isoforms, HEXDC catalyzes the hydrolysis of non-reducing N-acetyl-D-hexosamine residues near the termini of N-acetyl-beta-D-hexosaminides. The gene encoding HEXDC maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Defects in p53 is associated with malignant cell growth and Li-Fraumeni syndrome. BRCA1 is directly involved in DNA repair and is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Gen-ID: 284004