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FBXW7 Antikörper (AA 501-600) (Biotin)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FBXW7 in WB, ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN1398835

Kurzübersicht für FBXW7 Antikörper (AA 501-600) (Biotin) (ABIN1398835)

Target

Alle FBXW7 Antikörper anzeigen
FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reaktivität

  • 64
  • 38
  • 32
  • 16
  • 15
  • 14
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 56
  • 12
Kaninchen

Klonalität

  • 59
  • 9
Polyklonal

Konjugat

  • 38
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser FBXW7 Antikörper ist konjugiert mit Biotin

Applikation

  • 58
  • 24
  • 15
  • 14
  • 13
  • 13
  • 9
  • 5
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 14
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 501-600

    Kreuzreaktivität

    Human, Maus, Ratte

    Homologie

    Dog,Cow,Pig,Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Fbxw7/hCDC4

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

    Andere Bezeichnung

    Fbxw7

    Hintergrund

    Synonyms: AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10, F-box/WD repeat-containing protein 7, Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, FBXW7

    Background: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).

    Gen-ID

    55294

    UniProt

    Q969H0

    Pathways

    Notch Signalweg, EGFR Signaling Pathway
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