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RIT1 Antikörper (AA 141-219) (AbBy Fluor® 555)

This anti-RIT1 antibody (ABIN1398821) is a Rabbit Polyclonal antibody detecting RIT1 in WB, IF (cc), IF (p). Suitable for Human.
Produktnummer ABIN1398821

Kurzübersicht für RIT1 Antikörper (AA 141-219) (AbBy Fluor® 555) (ABIN1398821)

Target

Alle RIT1 Antikörper anzeigen
RIT1 (Ras-Like Without CAAX 1 (RIT1))

Reaktivität

  • 41
  • 17
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
Human

Wirt

  • 45
  • 3
Kaninchen

Klonalität

  • 46
  • 2
Polyklonal

Konjugat

  • 20
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser RIT1 Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation

  • 37
  • 19
  • 12
  • 12
  • 4
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 8
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 141-219

    Homologie

    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human RIT1

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    RIT1 (Ras-Like Without CAAX 1 (RIT1))

    Andere Bezeichnung

    RIT1

    Hintergrund

    Synonyms: GTP binding protein Roc1, GTP-binding protein Rit1, Ras like protein expressed in many tissues, Ras like without CAAX 1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1, RIBB, Ric like expressed in many tissues, RIT, RIT1, RIT1_HUMAN, ROC1.

    Background: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71 % and 66 % identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for C-terminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a C-terminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins

    Gen-ID

    6016

    Pathways

    Neurotrophin Signalübertragung
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