RTN4IP1 Antikörper (AA 111-210) (Biotin)

Produktnummer ABIN1398481

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RTN4IP1 in WB, ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für RTN4IP1 Antikörper (AA 111-210) (Biotin) (ABIN1398481)

Target: RTN4IP1 (Reticulon 4 Interacting Protein 1 (RTN4IP1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RTN4IP1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-RTN4IP1 Antikörper (Biotin)

Bindungsspezifität: AA 111-210

Kreuzreaktivität: Maus

Homologie: Human,Rat,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NIMP/RTN4IP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu RTN4IP1

Target: RTN4IP1 (Reticulon 4 Interacting Protein 1 (RTN4IP1))

Andere Bezeichnung: NIMP

Hintergrund:

Synonyms: mitochondrial, NIMP, NOGO interacting mitochondrial protein, NOGO-interacting mitochondrial protein, Reticulon 4 interacting protein 1, Reticulon 4 interacting protein 1, mitochondrial, Reticulon-4-interacting protein 1, RT4I1_HUMAN, Rtn4ip1, NIMP/RTN4IP1.

Background: Appears to be a potent inhibitor of regeneration following spinal cord injury.Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells, and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NIMP (NOGO-interacting mitochondrial protein), also known as RTN4IP1 (Reticulon-4-interacting protein 1), is a 396 amino acid mitochondrial protein that contains a C-terminal oxidoreductaselike domain and numerous sites for phosphorylation. NIMP is expressed in mitochondrial-rich tissue such as kidney, heart, skeletal muscle and specific regions within the nervous system. Through interaction with Nogo, it is likely that NIMP plays a role in Nogo-induced inhibition of neurite growth. There are three isoforms of NIMP that are produced as a result of alternative splicing events.

Gen-ID: 84816