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ATXN3L Antikörper (AA 251-355) (FITC)

This anti-ATXN3L antibody (ABIN1396645) is a Rabbit Polyclonal antibody detecting ATXN3L in WB, IF (cc), IF (p). Suitable for Human.
Produktnummer ABIN1396645

Kurzübersicht für ATXN3L Antikörper (AA 251-355) (FITC) (ABIN1396645)

Target

Alle ATXN3L Antikörper anzeigen
ATXN3L (Ataxin 3-Like (ATXN3L))

Reaktivität

  • 17
  • 1
Human

Wirt

  • 17
Kaninchen

Klonalität

  • 17
Polyklonal

Konjugat

  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ATXN3L Antikörper ist konjugiert mit FITC

Applikation

  • 17
  • 12
  • 12
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    AA 251-355

    Kreuzreaktivität

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human ATXN3L

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    ATXN3L (Ataxin 3-Like (ATXN3L))

    Andere Bezeichnung

    ATXN3L

    Hintergrund

    Synonyms: ATX3L_HUMAN, ATXN3L, Machado-Joseph disease protein 1-like, MJDL, Putative ataxin-3-like protein.

    Background: Defects in ATXN3 are the cause of spinocerebellar ataxia type 3 (SCA3) , also known as Machado-Joseph disease (MJD). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA3 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. The molecular defect in SCA3 is the a CAG repeat expansion in ATXN3 coding region. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.

    Gen-ID

    92552
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