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MEIS3 Antikörper (AA 121-220) (AbBy Fluor® 488)

This anti-MEIS3 antibody (ABIN1393924) is a Rabbit Polyclonal antibody detecting MEIS3 in WB, IF (cc), IF (p). Suitable for Rat.
Produktnummer ABIN1393924

Kurzübersicht für MEIS3 Antikörper (AA 121-220) (AbBy Fluor® 488) (ABIN1393924)

Target

Alle MEIS3 Antikörper anzeigen
MEIS3 (Meis Homeobox 3 (MEIS3))

Reaktivität

  • 29
  • 22
  • 8
  • 6
  • 5
  • 5
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Ratte

Wirt

  • 36
  • 7
Kaninchen

Klonalität

  • 38
  • 5
Polyklonal

Konjugat

  • 21
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MEIS3 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation

  • 38
  • 17
  • 12
  • 12
  • 5
  • 4
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 121-220

    Kreuzreaktivität

    Ratte

    Homologie

    Mouse,Dog,Sheep,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Meis homeobox 3

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    MEIS3 (Meis Homeobox 3 (MEIS3))

    Andere Bezeichnung

    Meis homeobox 3

    Hintergrund

    Synonyms: Homeobox protein meis3, Meis1 myeloid ecotropic viral integration site 1 homolog 3, Meis1 related protein 2, Meis1-related protein 2 antibodymeis3, MEIS3_HUMAN, MRG2.

    Background: Hox, Pbx and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Hox proteins are involved in regulating tissue patterning during development, and are also expressed in lineage- and stage-specific patterns during adult hematopoietic differentiation and in leukemias. The Hox proteins, which include paralog groups 1-10, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx- related Meis proteins, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site. Both Meis1 and Meis2 (also known as Meis-related gene 1 or Mrg1) are members of the TALE (three amino acid loop extension?) family of homeodomain-containing proteins. In addition to binding with Hox proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, including Pbx1, Pbx2 and Pbx3, and these complexes contain distinct DNA-binding specificities. Like Hox and Pbx proteins, Meis1 is implicated in oncogenesis, as it is overexpressed as a result of adjacent retroviral insertion in BHX-2 myeloid leukemias. Two Meis-related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and are expressed in normal tissues and myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas-specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation.

    Pathways

    Chromatin Binding
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