ZFHX3 Antikörper (AA 301-400) (Biotin)

Produktnummer ABIN1393429

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ZFHX3 in ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für ZFHX3 Antikörper (AA 301-400) (Biotin) (ABIN1393429)

Target: ZFHX3 (Zinc Finger Homeobox 3 (ZFHX3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZFHX3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ZFHX3 Antikörper (Biotin)

Bindungsspezifität: AA 301-400

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ATBF1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu ZFHX3

Target: ZFHX3 (Zinc Finger Homeobox 3 (ZFHX3))

Andere Bezeichnung: ATBF1

Hintergrund:

Synonyms: Alpha fetoprotein enhancer binding protein, AT binding transcription factor 1, AT mot binding factor, ATBT, ZFHX3, ZFHX3_HUMAN.

Background: AT-motif binding factor 1 (ATBF1) binds to the AT-rich core sequence element in the human a-fetoprotein enhancer (1). Alternative splicing generates the ATBF1-A and ATBF1-B (2,3). While ATBF1-A contains a 920-amino acid extension at the N-terminus, both ATBF1-A and ATBF1-B contain 4 DNA-binding homeobox domains (2,3). Additionally, ATBF1-A contains 23 zinc finger motifs while ATBF1-B contains 18 zinc finger motifs (13). The N-terminal extension unique to ATBF1-A has transcriptional repressor activity (4). In the small intestine, ATBF1-A inhibits expression of the brushborder enzyme aminopeptidase-N through direct binding to the AT motif element (5). Besides functioning in transcription regulation, ATBF1 also functions in ATPase activity (6). ATPase activity associated with ATBF1-A is DNA/RNA-dependent and requires both homeobox domains and zinc finger motifs (6). ATBF1 is highly expressed in spleen and brain tissues (7). The gene encoding human ATBF1 maps to chromosome 16q22.3-q23.1 (8).

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development