TTBK2 Antikörper (AA 1151-1244) (AbBy Fluor® 647)

Produktnummer ABIN1393224

This anti-TTBK2 antibody (ABIN1393224) is a Rabbit Polyclonal antibody detecting TTBK2 in WB, IF (cc), IF (p). Suitable for Human.

Kurzübersicht für TTBK2 Antikörper (AA 1151-1244) (AbBy Fluor® 647) (ABIN1393224)

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TTBK2 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-TTBK2 Antikörper (AbBy Fluor® 647)

Bindungsspezifität: AA 1151-1244

Homologie: Human,Mouse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TTBK2/SCA11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu TTBK2

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Andere Bezeichnung: TTBK2/SCA11

Hintergrund:

Synonyms: TTBK2/SCA11 Tau tubulin kinase 2, Spinocerebellar ataxia 11, Tau tubulin kinase 2, Tau-tubulin kinase 2, TTBK, TTBK 2, TTBK1, TTBK2 , TTBK2_HUMAN, TTK, KIAA0847, mKIAA0847, SCA11.

Background: SCA11 is a 1,244 amino acid protein that belongs to the protein kinase superfamily and the CK1 Ser/Thr protein kinase family. The SCA11 gene, comprising of 16 exons, produces a 5.6-kb transcript in which the longest open reading frame is 3,732 nucleotides. Defects in the SCA11 protein are the cause of the disorder spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The SCA11 disorder is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. The SCA11 protein has also been implicated in Alzheimer disease and in tangle formation. Existing as three alternatively spliced isoforms, the SCA11 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 15q15.2.