PICALM Antikörper (AA 251-350) (Biotin)

Produktnummer ABIN1392613

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PICALM in WB, ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für PICALM Antikörper (AA 251-350) (Biotin) (ABIN1392613)

Target: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PICALM Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-PICALM Antikörper (Biotin)

Bindungsspezifität: AA 251-350

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep,Horse,Zebrafish

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PICALM/CALM

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu PICALM

Target: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Andere Bezeichnung: PICALM/CALM

Hintergrund:

Synonyms: Clathrin assembly lymphoid myeloid leukemia, Clathrin assembly lymphoid myeloid leukemia protein, CLTH, LAP, Phosphatidylinositol-binding clathrin assembly protein, PICAL_HUMAN, PICALM.

Background: Clathrin-coated pits and vesicles are assembled for receptor-mediated endocytosis through interaction with clathrin associated protein complexes. Vesicle transport is mediated from the trans-Golgi network by the adapter complex AP-1 and from the plasma membrane by the AP-2 complex. The AP-1 and AP-2 adapter protein complexes consist of clathrin binding adaptin proteins and two smaller subunits known as AP50 and AP17. The Alpha- and Beta-Adaptin chains have a similar two-domain organization with C-terminal domains that vary in both sequence and length. Alpha-Adaptin splice variants A and C display variable relative expression levels and differential distribution in different tissues. AP180 (also designated AP-3 or F1-20) is a synapse-specific clathrin assembly protein. The protein CALM (clathrin assembly protein lymphoid myeloid leukemia) is highly homologous to AP180 and may also be involved in clathrin assembly.

Pathways: Synaptic Membrane