OTX2 Antikörper (AA 15-105) (Biotin)
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- Target Alle OTX2 Antikörper anzeigen
- OTX2 (Orthodenticle Homeobox 2 (OTX2))
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Bindungsspezifität
- AA 15-105
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser OTX2 Antikörper ist konjugiert mit Biotin
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Ratte
- Homologie
- Human,Mouse,Dog,Cow,Sheep,Horse,Chicken
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human OTX2
- Isotyp
- IgG
- Top Product
- Discover our top product OTX2 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- OTX2 (Orthodenticle Homeobox 2 (OTX2))
- Andere Bezeichnung
- OTX2 (OTX2 Produkte)
- Synonyme
- CPHD6 antikoerper, MCOPS5 antikoerper, E130306E05Rik antikoerper, id:ibd2915 antikoerper, zOtx2 antikoerper, zgc:136535 antikoerper, zotx-2 antikoerper, Xotx-2 antikoerper, Xotx2 antikoerper, otx-2 antikoerper, otx2 antikoerper, orthodenticle homeobox 2 antikoerper, orthodenticle homeobox 2 S homeolog antikoerper, orthodenticle homeobox 2 L homeolog antikoerper, OTX2 antikoerper, Otx2 antikoerper, otx2 antikoerper, otx2.S antikoerper, otx2.L antikoerper
- Hintergrund
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Synonyms: CPHD6, Homeobox protein OTX2, MCOPS 5, MCOPS5, MGC45000, Orthodenticle 2, Orthodenticle homeobox 2, Orthodenticle homolog 2 Drosophila, Orthodenticle homolog 2, Orthodenticle2, Otx 2, otx2, OTX2_HUMAN.
Background: Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively.
- Pathways
- Dopaminergic Neurogenesis
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