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Hippocalcin Antikörper (AA 101-193) (Biotin)

HPCA Reaktivität: Maus WB, ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1390741
  • Target Alle Hippocalcin (HPCA) Antikörper anzeigen
    Hippocalcin (HPCA)
    Bindungsspezifität
    • 14
    • 8
    • 6
    • 2
    AA 101-193
    Reaktivität
    • 31
    • 26
    • 9
    Maus
    Wirt
    • 38
    • 2
    Kaninchen
    Klonalität
    • 39
    • 1
    Polyklonal
    Konjugat
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Hippocalcin Antikörper ist konjugiert mit Biotin
    Applikation
    • 32
    • 16
    • 13
    • 13
    • 13
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Cow,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Hippocalcin
    Isotyp
    IgG
    Top Product
    Discover our top product HPCA Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    Hippocalcin (HPCA)
    Andere Bezeichnung
    Hippocalcin (HPCA Produkte)
    Synonyme
    zgc:73126 antikoerper, MGC80408 antikoerper, MGC84992 antikoerper, bdr2 antikoerper, BDR2 antikoerper, hippocalcin antikoerper, hippocalcin S homeolog antikoerper, hpca antikoerper, hpca.S antikoerper, HPCA antikoerper, Hpca antikoerper
    Hintergrund

    Synonyms: BDR 2, BDR2, Calcium binding protein BDR 2, Calcium binding protein BDR2, Calcium-binding protein BDR-2, Hpca, HPCA_HUMAN, Neuron specic calcium binding protein hippocalcin, Neuron specic calcium-binding protein hippocalcin, Neuron-specic calcium-binding protein hippocalcin,P23K.

    Background: Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.

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